Supplementary Figure S7 from Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma.
Year: 2024
Type: supplementary-materials
Abstract: Hi-C interaction and TAD map of TI2 and G8 regions. A comparison of the chromatin conformation of the region which encompasses TI2 and G8 across the 3 HMCLs (U266, RPMI8226, and KMS11) and PC. We note that there are noticeable loss of TAD boundary within the G8 region between PC and U266 and RPMI8226 that may allow accessibility to distal super-enhancers and result in overexpression. A similar change is seen in KMS11 at the ELF3 locus.
Authors: Eileen M. Boyle, Patrick Blaney, James H. Stoeckle, Yubao Wang, Hussein Ghamlouch, Dylan Gagler, Marc Braunstein, Louis Williams, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, Jason Avigan, Alexander Li, Monica Jinsi, David Kaminetzky, Arnaldo Arbini, Lydia Montes, Jill Corre, Even H. Rustad, Ola Landgren, Francesco Maura, Brian A. Walker, Michael Bauer, Benedetto Bruno, Aristotelis Tsirigos, Faith E. Davies, Gareth J. Morgan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402817703