Year: 2024
Type: article
Abstract: Questions of the etiology and pathogenesis of vitiligo remain open to this day. Of the majority of hypotheses for the development of vitiligo, the leading role today belongs to the autoimmune theory. The most relevant for solving issues of both therapy and diagnosis of the disease are studies devoted to the immunological mechanisms accompanying the development of vitiligo. The article describes both immunological markers of autoimmune diseases of satellites and changes in immunity during the disease itself. The question of the activity of the process sometimes causes great difficulties, both for the doctor, and the patient himself sometimes cannot say for sure whether there is a growth of foci, especially with a widespread process. In the article we touched upon the issues of consideration and immunological markers, which, according to pilot studies, can serve as laboratory indicators of activity. The roles of interleukin 17, imbalance between subpopulations of T-helper lymphocytes type 1 (Th 1) or Th 17 and Tregs and Th 2, cytokine imbalance, JAK1 and JAK2 kinases, CXCL 9, CXCL 10, granzyme B are described.
DOI: 10.21518/ms2024-317
Author: V. V. Petunina
Institution: Pirogov Russian National Research Medical University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4402819109