Synthesis, conformational analysis and biological activity evaluation of novel antiviral peptides blocking the SARS-CoV-2 cell-entry
Year: 2024
Type: conference-paper
Abstract: Synthesis, conformational analysis and biological activity evaluation of novel antiviral peptides blocking the SARS-CoV-2 cell-entryReferences Peptide Sequence IC 50 (mean ± SD) µM a Sequence Peptide 2.80±2.68Ac-SGWTFGAGAALQIPFAMQMAYRF-NH 2 IFP 0.71±2.11Ac-WTFGAGAALQIPFAMQMAYRF-NH 2 PN21 ACE2(24-42) Ac-QAKTFLDKFNHEAEDLFYQ-NH 2 >100 0.20±1.11Ac-FGAGAALQIPFAMQMAYRF-NH 2 PN19 2.79±1.96Ac-AGAALQIPFAMQMAYRF-NH 2 PN17 P1 >100 8.33±3.60Ac-SGWTFGAGAALQIPFAMQMAY-NH 2 PC21 9.43±2.44Ac-SGWTFGAGAALQIPFAMQM-NH 2 PC19 P2 >100 97.94±21.84Ac-SGWTFGAGAALQIPFAM-NH 2 PC17 46.83±9.97Ac-WTFGAGAALQIPFAMQMAY-NH 2 PNC19 P3 8.89±6.03>100 Ac-FGAGAALQIPFAMQM-NH 2 PNC15 1.70±0.52Ac-LQIPFAMQMAYRF-NH 2 PN13 P4 >100 5.93±9.74Ac-FAMQMAYRF-NH 2 PN9 a IC 50 values are measured by inhibitory viral plaque reduction assay (PRA) on Vero E6 cells.
Source: European Peptide Symposium (EPS)
Authors: M. Quagliata, M.A. Stincarelli, A. Di Santo, L. Pacini, F. Real-Fernandez, R. Arvia, S. Rinaldi, S. Giannecchini, A.M. Papini, P. Rovero
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4402846733