Work

Nanocomposite Hydrogels from Nanodiamonds and a Self‐Assembling Tripeptide

Year: 2024

Type: article

Abstract: We report the successful assembly of a tripeptide in the presence of nanodiamonds (NDs) into nanocomposite hydrogels. While the presence of NDs does not hinder peptide self-assembly and gelation kinetics are not affected, NDs improve the viscoelastic properties and significantly increase the elastic moduli of the peptide hydrogels. Increased resistance of the gels against applied stress can also be attained depending on the amount of NDs loaded in the nanocomposite. Raman micro-spectroscopy and TEM confirmed the presence of NDs on the surface, and not in the interior, of peptide nanofibers. Peptide-ND non-covalent interactions are also probed by Raman and Fourier-transformed infrared spectroscopies. Overall, this work enables the embedding of NDs into nanocomposite hydrogels formed through the self-assembly of a simple tripeptide at physiological pH, and it provides key insights to open the way for their future applications in biomaterials, for instance exploiting their luminescence and near-infrared responsiveness.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202402961

Authors: Davide Marin, Slavko Kralj, Stepan Stehlik, Silvia Marchesan

Institutions: University of Trieste, University of Ljubljana, Jožef Stefan Institute, Jožef Stefan International Postgraduate School, Czech Academy of Sciences, FZU - Institute of Physics of the Czech Academy of Sciences, University of West Bohemia in Pilsen

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funders: European Cooperation in Science and Technology, Grantová Agentura České Republiky, Ministero dell’Istruzione, dell’Università e della Ricerca, Javna Agencija za Raziskovalno Dejavnost RS, Università degli Studi di Trieste, Ministero dell'Università e della Ricerca

Awards: G1660389418, G2910440034, G2936623597, G3532786923, G4042514441, Multifunctional nanotools for advanced cancer diagnostics, Magnetically-controllable nanocarriers mimicking endogenous lipid particles for improved drug/nanoparticle delivery, Selective electroporation by distributed nanoelectrodes, G540338838, Bactericidal nanoblades: a proof-of-concept approach for bimodal chemo-mechanical eradication of persistent biofilms, Selective mechanical removal of bacterial biofilms by conjugated magnetic nanoparticles, Advanced magnetic and multifunctional materials, Exploitation of the magneto-mechanical effect in the treatment of neurodegenerative diseases, G8324119797, Nanodiamonds as selective protein traps to regulate disorders caused by aberrant FGF2 signaling

OpenAlex ID: W4402859516

FWCI: 0.336

Cites: 43

Cited by: 4

Related to: 10