Year: 2024
Type: article
Abstract: 3D Printed Ti-based implants and scaffolds have gained substantial attention in the medical field. These medical multi-metals have shown significant achievements in terms of their mechanical, antibacterial, angiogenic properties, and immune regulatory functions. This has led to breakthrough improvements in osteogenesis. Both the physicochemical properties (roughness, hydrophilicity, and corrosion resistance) and mechanical properties (pore shape, pore size, and porosity) of 3D Printed porous Ti-alloys directly affect osteogenesis. The structure of the pores and the presence of different types of metal in these alloys may promote osteogenesis by stimulating the polarisation of macrophages from M1 to M2. It may also induce angiogenesis by regulating the expression of angiogenesis-related genes that encode proteins such as VEGF. Neovascularization around these implants may rapidly induce contact osteogenesis and bone integration. This review elucidates the mechanisms by which 3D Printed porous Ti alloys affect osteogenesis and provides important insights and directions for the development of 3D Printed Ti-based multimaterials.
Source: Virtual and Physical Prototyping
Authors: Linxi Zhou, Ying Liu, Heng You, Wanxin Zheng, Jiaxing Huo, Wenzhe Xu, Xiyue Zhang, Wei Zhang, Qiang Wang, Bing Fang
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,070
Awards: G3958908283, G5954187921
OpenAlex ID: W4402864341