Work

Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account

Year: 2024

Type: article

Abstract: Fluoroalkenes have been known for decades, but their preparation is still a hot topic. Indeed, the olefination reactions of carbonyl compounds with fluorinated derivatives are not trivial. For that reason, new tools have been developed to efficiently access tri- and tetrasubstituted alkenes. We report our contribution in this field and their interest will be illustrated by the preparation of dipeptide isosteres and acyclonucleoside analogues.

Source: Comptes Rendus Chimie

DOI: 10.5802/crchim.337

Authors: Thierry Lequeux, Emmanuel Pfund

Institution: Laboratoire de Chimie Moléculaire et Thioorganique

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

Funder: Agence Nationale de la Recherche

Award: Synthèse Organique : des molécules au vivant