Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background To explore the genetic causal association between lymphoma and the circulating levels of vitamins through Mendelian randomization (MR).Research design and methods We performed MR analysis using publicly available genome-wide association study (GWAS) summary data. Seven indicators related to the circulating levels of vitamins (vitamin D, vitamin C, vitamin B6, vitamin B12, folic acid, vitamin E, and carotene) served as exposures, while lymphoma was the outcome. The genetic causal association between these circulating levels of vitamin indicators and lymphoma was assessed using the inverse variance weighted (IVW) method.Results Based on IVW method, vitamin B12 (OR = 0.48; 95% CI: 0.28–5.19; p = 0.018) and folic acid (OR = 0.62; 95% CI: 0.40–0.96; p = 0.032) both showed substantial evidence of a relationship with lymphoma. Moreover, the Weighted median method similarly indicated potential evidence of an association between vitamin B12 (OR = 0.40; 95% CI: 0.18–0.90; p = 0.027) and lymphoma. The Simple mode, and Weighted mode methods showed no potential genetic causal association (p > 0.05 in the two analyses).Conclusions This study suggests a potential association between folic acid and vitamin B12 and lymphoma. Further research is required to assess the reproducibility of this finding in different contexts and to gain deeper insights into the potential underlying mechanisms.
Source: Expert Review of Hematology
Authors: Yan-Yan Rong, Peng-Cheng Liu, Xian-Bao Huang, Guo-An Chen
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G4506844550
OpenAlex ID: W4402865722