Work

Visible Light Photocatalyzed Norrish Type II Reaction of Acrylamides for the Synthesis of β‐Lactams

Year: 2024

Type: article

Abstract: Here, we present a strategy for the visible‐light‐catalyzed synthesis of β‐lactams based on the Norrish type II reaction. This protocol uses acetonitrile as solvent and commercially available photocatalyst to drive the reaction. Notably, various challenging substrate types reported in previous studies undergo conversion. DFT calculations further elucidate the reaction mechanism, while discussing the competitiveness between [2+2] cycloaddition and the Norrish II reaction.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202400976

Authors: Hao‐Yuan Li, Shen‐Zhen Zhang, Xiaoying Niu, Qing‐Yuan Meng, Xiu‐Long Yang

Institutions: Hebei University, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, University of Chinese Academy of Sciences

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Natural Science Foundation of Hebei Province, Hebei University