Work

HBx induces chemoresistance in diffuse large B cell lymphoma by inhibiting intrinsic apoptosis via the NF-κB/XIAP pathway

Year: 2024

Type: article

Abstract: experiments, our study demonstrates that the HBx antigen triggers excessive activation of the NF-κB pathway, resulting in increased expression of the X-linked inhibitor of apoptosis protein (XIAP). This upregulation inhibits caspase-3-mediated intrinsic apoptosis and enhances resistance to first-line chemotherapeutic agents like epirubicin and vincristine in DLBCL. These findings offer insights into the development of innovative combination therapies for DLBCL patients with HBV infection.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2024.102346