Work

A limited sampling model to estimate the area under the curve of mycophenolic acid in hematopoietic stem cell transplantation recipients

Year: 2024

Type: article

Abstract: Relationship between the areas under the curve (AUC) of mycophenolic acid (MPA) and the likelihood of rejection is well‐established in solid organ transplantation recipients. In hematopoietic stem cell transplantation (HSCT), MPA AUC is also linked to graft versus host disease. This study aimed to develop a simplified method to estimate MPA AUC0–12 in Chinese patients undergoing allogeneic HSCT (allo‐HSCT). Intensive sampling was conducted in 22 patients who were orally administered mycophenolate mofetil. Plasma concentrations of total MPA were measured, and a model predicting AUC0–12 using data from these 22 patients was constructed through regression analysis. The accuracy of the most suitable model was assessed in an additional 20 patients. None of the individual MPA concentrations showed a strong correlation with AUC0–12 (r2 < 0.7). Models utilizing 4 or more concentrations were found to effectively estimate MPA AUC0–12 (r2 > 0.87). The most operationally feasible model demonstrated good predictive performance with a mean absolute percentage error (APE%) < 20%. Single MPA concentrations showed poor correlation with MPA AUC0–12. A model utilizing 4 oral concentrations (0, 0.5, 1, and 4 h postdose) over a 12‐h period could effectively estimate MPA AUC0–12 with precise results and minimal bias.

Source: Biopharmaceutics & Drug Disposition

DOI: 10.1002/bdd.2399

Authors: Liangmo Lin, Mianhui Hong, Xiangjun Fu

Institutions: Hainan General Hospital, Hainan Medical University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,620