Work

Room Temperature Regioselective Debenzylative Cycloetherification Reaction

Year: 2024

Type: article

Abstract: A regio- and stereoselective debenzylative cycloetherification (DBCE) reaction of protected hexoses to form stereodefined hydroxylated tetrahydrofurans of synthetic utility has been investigated under very mild room temperature reaction conditions. This study revealed the potential application of the DBCE reaction of simple, abundant starting materials to access stereochemically rich tetrahydrofuran compounds under mild reaction conditions.

Source: ACS Omega

DOI: 10.1021/acsomega.4c04016

Authors: Samuel Kwain, Colin D. McMillen, Daniel C. Whitehead

Institution: Clemson University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: National Institutes of Health, National Institute of General Medical Sciences