Year: 2024
Type: article
Abstract: Recent developments in the isotopic labeling of heteroarenes may prove to be useful in the realms of biomedical science, materials chemistry, and fundamental organic chemistry. The use of the age-old Zincke reaction, or tactical variants thereof, has become particularly utilitarian in effecting single-atom nitrogen replacement in various azines to generate their desired isotopologues. This chemistry can be synthetically leveraged at an early stage for diversity-oriented heterocyclic labeling of pharmaceuticals and/or natural products. Additionally, given the prevalence of saturated azacycles in biologically relevant molecules, access to these isotopologues becomes relevant through dearomative retrosynthetic analysis from the corresponding 15N-labeled heteroarenes. 1 Introduction 2 Our Lab’s Development of the 15NRORC Reaction 3 Other Recent Azine-Labeling Methods 4 Expanded ANRORC Utilization 5 Conclusion and Outlook
Source: Synlett
Author: Joel M. Smith
Institution: Florida State University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
Awards: G1383834035, G274105738
OpenAlex ID: W4402884306