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Multiple Oral Manifestations in a Patient With Chronic Graft Versus Host Disease: A Case Report

Year: 2024

Type: article

Abstract: Hematopoietic stem cell transplantation (HSCT) is the standard treatment for hematopoietic malignancies and certain solid tumors; however, graft-versus-host disease (GVHD) remains a significant complication. Chronic GVHD (cGVHD), which occurs more than 100 days post-transplant, can lead to various oral manifestations that necessitate multidisciplinary management to prevent disease progression and enhance the quality of life. We present the case of a 60-year-old woman who developed dry mouth, oral pain, a brown-yellow tongue, and dental caries seven years after receiving HLA-matched unrelated donor HSCT. Examination revealed a brown-yellow hairy tongue, extensive tooth decay, reduced saliva production, and oral leukoplakia with mild epithelial hyperplasia, along with dysfunction of the salivary and lacrimal glands. Following appropriate treatment, the patient's symptoms resolved without recurrence at the six-month follow-up. This case highlights the importance of professional diagnosis, timely interventions, and regular monitoring in managing oral cGVHD to achieve a favorable prognosis.

Source: Cureus

DOI: 10.7759/cureus.70233

Authors: Duo Li, Yidan Shan, Weilian Sun, Xiangjian Wang

Institutions: Ningbo University, Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Oral health in cancer treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402887491