Macular Volume Scan as a Marker of Angiographic Uveitic Retinal Vasculitis
Year: 2024
Type: article
Study design: Observational Study
Abstract: PURPOSE: To determine whether optical coherence tomography thickness values from macular volume scans can be used to detect uveitic retinal vasculitis. METHODS: Retrospective study of patients with noninfectious retinal vasculitis. Fluorescein angiogram and 61-line optical coherence tomography macular volume scans with an overlying Early Treatment Diabetic Retinopathy study grid were obtained. Correlation between 1 mm and 6 mm Early Treatment Diabetic Retinopathy study ring values and posterior pole vasculitis was analyzed. A linear longitudinal model was used to assess the relationship between global retinal vasculitis scores and optical coherence tomography macular thickness parameters. RESULTS: Ninety-nine eyes of 54 patients were included. A total of 460 optical coherence tomography and fluorescein angiogram pairs were analyzed. Central (1 mm) macular thickness was weakly correlated with posterior pole vasculitis (correlation coefficient [rho] = 0.09, P = 0.06). Both the mean 6 mm ring (rho = 0.11, P = 0.018) and the average of the superior and inferior (S/I) 6 mm ring values (rho = 0.13, P = 0.006) were strongly correlated with posterior pole leakage. The longitudinal model showed that S/I 6 mm ring values are associated with vasculitis in the posterior pole, mid, and far periphery ( P < 0.0001). CONCLUSION: Optical coherence tomography-based macular volume thickness can detect uveitic retinal vasculitis and aid in monitoring disease activity.
Source: Retina
Institutions: Northwestern University, Associated Retinal Consultants
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4402891725