ole of Spot Urinary Calcium Creatinine Ratio as A Non-Invasive Biomarker for Predicting Pre-Eclampsia
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Pre-eclampsia leads to maternal and foetal death.Early discovery improves results, however existing diagnostic procedures generally fail to forecast the condition's beginning.The urine calcium-creatinine ratio (UCCR) may be a non-invasive diagnostic for pre-eclampsia identification due to abnormal calcium metabolism in afflicted pregnancies.Aim: To investigate the predictive value of UCCR as a biomarker for the early detection of pre-eclampsia in pregnant women.Methods: A prospective cohort study comprised one hundred expectant mothers.Pre-eclampsia was watched for in the participants.Samples of urine were collected at 20 and 24 weeks to assess UCCR.Up to delivery, participants' pre-eclampsia was observed.The ROC analysis was utilised to assess the predictive accuracy of the UCCR after its sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were computed.Results: The average age and weight of the study population were 26.47 years (±5.26) and 62.66 kg (±5.34), respectively.92% of participants lived in cities, and 82% of them were primigravidae.For 91% of the women, vaginal birth was the usual mode of delivery.The UCCR values of women with pre-eclampsia were substantially lower than those of non-eclamptic women (p < 0.001).An Area Under the Curve (AUC) of 0.961 was shown by the ROC analysis, suggesting strong prediction accuracy.With a positive predictive value of 29.4% and a negative predictive value of 100%, the ideal UCCR cut-off value of 0.0650 produced a sensitivity of 100% and a specificity of 73.3%.Conclusion: UCCR is a promising non-invasive biomarker for the early detection of pre-eclampsia, with high sensitivity and NPV.However, its moderate specificity suggests it should be used alongside other clinical assessments.Recommendations: Further large-scale studies are recommended to validate the UCCR cut-off values and refine its use in clinical practice, potentially integrating it into routine antenatal screening protocols for early intervention.
Author: Rajalaxmi Moharana
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402891922