Work

Niosomes loaded with gold nanoparticles for enhanced radiation therapy in lung cancer

Year: 2024

Type: article

Abstract: Aim: The present investigation aimed to develop niosomes containing gold nanoparticles (Nio-AuNPs) and to evaluate the combinational effect of Nio-AuNPs and x-ray radiation therapy (XRT) on growth inhibition potential and induction of apoptosis in the A549 cell line.Materials & methods: Gold nanoparticles (AuNPs) were synthesized, and niosomes were prepared using the thin-film hydration method. Various techniques were employed to determine their physiochemical characteristics. MTT assay, cell apoptosis analysis and combination index analysis were conducted to evaluate the therapeutic feasibility of Nio-AuNPs combined with XRT.Results: The combination of Nio-AuNPs and XRT resulted in greater cytotoxicity compared with XRT alone or with AuNPs.Conclusion: The AuNPs-loaded niosomal formulation enhances the efficacy of XRT on lung cancer cells in vitro, presenting a promising and effective therapeutic strategy.

Source: Nanomedicine

DOI: 10.1080/17435889.2024.2393071

Authors: Ramezan Ali Taheri, Hamidreza Fathi, Ali Sharafi, Morteza Mirzaei, Shima Jafari, Mohammad Hasan Darvishi

Institutions: Baqiyatallah University of Medical Sciences, Tabriz University of Medical Sciences, Zanjan University of Medical Sciences

Language: English

Topic: Radiation Therapy and Dosimetry

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Baqiyatallah University of Medical Sciences, Zanjan University of Medical Sciences, University of Zanjan