Figure 2 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Year: 2024
Type: other
Abstract: SCAP is required for human PDAC tumor growth in mouse subcutaneous xenograft models. A, Nude mice were subcutaneously injected with 5 × 105 Pa03c cells in both flanks (two tumors per mouse). Once visible, tumors were measured, and volume calculated. Each group contained six mice. Error bar denotes SD. Statistical significance was determined using the Student t test. P values are indicated: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant. B, Individual tumor volumes at day 22, n = 12 tumors per group. Statistical significance was determined using the Student t test. C, Representative hematoxylin and eosin–stained sections of formalin-fixed tumor tissue from the mice in A showing a low magnification (4×) image (top row) and a higher magnification (20×) image (bottom row) of tumor sections. D, Nude mice were subcutaneously injected with 1 × 106 Pa16c cells in both flanks (two tumors per mouse) as in A–C. Each group contained six mice. Error bar denotes SD. Statistical significance was determined using the Student t test. P values are indicated: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant. E, Individual tumor volumes at day 61, n = 12 tumors per group. Statistical significance was determined using the Student t test. F, Representative hematoxylin and eosin–stained sections of formalin-fixed tumor tissue from the mice in D showing a low magnification (2–4×) image (top row) and a higher magnification (20–40×) image (bottom row) of tumor sections. WT, wild-type.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4402900712