Work

Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma

Year: 2024

Type: article

Abstract: Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a high-grade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3% of all UPSs. Case Presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma. Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.

Source: Ocular Oncology and Pathology

DOI: 10.1159/000541063

Authors: Sodaba Khatab, Johanna Maria Colijn, Nicole Naus, Robert M. Verdijk, Gijsbert Hötte

Institutions: Rotterdam Eye Hospital, Erasmus MC, Leiden University Medical Center

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4402903361