Work

Adaptive Self-Defense of Mature Cells against Damage Is Based on the Warburg Effect, De-Differentiation of Cells and Resistance to Cell Death

Year: 2024

Type: article

Abstract: This review analyzes the hypothesis of the preserved ability of various specialized mammalian cells to protect themselves from lethal injury by enacting a protective atavistic mechanism of cell dedifferentiation. The development of such protection is accompanied by a transition of differentiated cells from the mitochondrial oxygen-dependent type of metabolism to regenerative oxygen-independent metabolism (called the Warburg effect). This transition allows cells to increase the resistance to cell death from hypoxia, and can also induce the emergence of fetal markers characteristic of cell dedifferentiation. This paper, exemplified by the development of two pathologies (heart failure and type 2 diabetes), presents the findings that confirm the existence of such a mechanism and ways of its possible correction.

Source: Биофизика

DOI: 10.31857/s0006302924040105

Author: P. M Schwartsburd

Institutions: Russian Academy of Sciences, Institute of Theoretical and Experimental Biophysics

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4402917987

FWCI:

Cites: 31

Cited by:

Related to: 10