Antiviral Activity of Pd(II) Complexes with Aminoadamantanes Against Arboviruses
Year: 2024
Type: article
Abstract: In this paper, we report the synthesis, structural characterization, and antiviral properties of palladium(II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass spectrometric analyses indicated a 1:2 metal/ligand ratio. The single crystal data for Pd‐mtn revealed that the complex adopts a square geometry with the two memantine ligands bonded to Pd(II) by the nitrogen atoms of the NH 2 group, in a trans configuration. Computational studies supported a similar structure for Pd‐atd. The complexes were stable in DMSO solution for 24 h. The antiviral properties of Pd‐atd and Pd‐mtn were evaluated against Zika (ZIKV) and Chikungunya (CHIKV) viruses in vitro at their highest noncytotoxic concentrations. The Pd‐atd (at 2 µM) and Pd‐mtn (at 10 µM) complexes were able to impair 76% and 96% of CHIKV replication, respectively, which points the coordination of amantadine and memantine to Pd(II) as a successful strategy to increase their anti‐CHIKV properties. Conversely, the Pd(II) complexes did not significantly inhibit the replication of ZIKV, which confirms the selectivity towards CHIKV. Interaction of the compounds with N ‐acetyl‐ l ‐cysteine, a model disulfide‐containing peptide, and plasmid DNA pointed to Cys‐containing peptides as more likely targets than nucleotides for the complexes.
Source: ChemistrySelect
Authors: Laura Barros Silva, Állefe Barbosa Cruz, Douglas Henrique Pereira, Natasha Marques Cassani, Uriel Enrique Aquino Ruiz, Igor Andrade Santos, Daniel Oliveira Silva Martins, Douglas Hideki Nakahata, Déborah de Alencar Simoni, Ioannis Kanavos, Luisa Ronga, Ryszard Lobinski, Anna Karla dos Santos Pereira, Ana Carolina Gomes Jardim, Raphael Enoque Ferraz de Paiva, Pedro Paulo Corbi
Institutions: Universidade Estadual de Campinas (UNICAMP), Universidade Federal do Tocantins, Instituto Tecnológico de Aeronáutica, Universidade Federal de Uberlândia, Universidade Estadual Paulista (Unesp), Donostia International Physics Center, Centre National de la Recherche Scientifique, Université de Pau et des Pays de l'Adour, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G121811674, G1793032049, G187716650, G2037776927, “COMPLEXOS METÁLICOS COMO ABORDAGEM INOVADORA NO DESENVOLVIMENTO DE FÁRMACOS CONTRA VÍRUS EMERGENTES”, G2470147723, G3093826157, Computational and theoretical developments based on ab initio methods and the Density Functional Theory, G348902228, Cancer Theranostics Innovation Center (CancerThera), G4480242175, G5630499392, Synthesis of copper, silver and gold complexes involving nucleotide analogues in the search of new alternatives for the treatment of ovarian cancer, G598773271, G6709287323, G7254659350
OpenAlex ID: W4402918526