Understanding m6A changes in chromophobe renal cell carcinoma and predicting patient outcomes survival
Year: 2024
Type: article
Abstract: N6-methyladenosine (m 6 A) is a prevalent mRNA modification known for its implications in various cancer types, yet its role in chromophobe renal cell carcinoma (chRCC) remains largely unexplored. In this study, we performed m6A-SEAL-seq and RNA-seq analyses on tissues from three chRCC subjects, aiming to uncover m 6 A alterations in chRCC. Our findings revealed reduced expression levels of four m 6 A regulators in chRCC tissues and highlighted differences in m 6 A levels compared to normal tissues. Furthermore, we identified specific genes and cancer-related pathways affected by these differences, including notable candidates like NOTCH1 and FGFR1, implicated in chRCC development. Additionally, we developed a predictive model based on the expression level of m 6 A associated genes, demonstrating promising prognostic capabilities for patient survival prediction. Overall, our study provides valuable insights into the role of m 6 A in chRCC and its potential as a prognostic indicator.
Source: BMC Cancer
Authors: Zhigang Chen, Junbo Yang, Wei Zhang, Yang Qian, Nan Zhang, Zixin Chen, Min Lu, Liyuan Ge, Cheng Liu, Xiaojun Tian, Guifang Jia, Lulin Ma, Baoguo Li
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,190
Awards: G5792717849, G6426164040, G7293984919
OpenAlex ID: W4402920172