Work

RRAGD variants cause cardiac dysfunction in a zebrafish model

Year: 2024

Type: article

Abstract: The resultant heart-associated phenotypes in the zebrafish embryos of this study serve as a valuable experimental model for this rare cardiomyopathy. Moreover, the potential therapeutic property of rapamycin in cardiac dysfunctions was highlighted, making this study a pivotal step toward prospective clinical applications.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00705.2023

Authors: Anastasia Adella, Faris Tengku, Francisco J. Arjona, Sanne Broekman, Erik de Vrieze, Erwin van Wijk, Joost G. J. Hoenderop, Jeroen H. F. de Baaij

Institutions: Radboud University Nijmegen, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences

Language: English

Topic: Zebrafish Biomedical Research Applications

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Radboud Universiteit, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, European Research Council

Awards: G6462838852, G8115213849

OpenAlex ID: W4402920434

FWCI: 0.949

Cites: 28

Cited by: 5

Related to: 10