Work

Hypoxia-inducible factor-2α enhances neutrophil survival to promote cardiac injury following myocardial infarction

Year: 2024

Type: article

Abstract: Hif2α in neutrophils increases infarct size, cardiac dysfunction, and ventricular scar after myocardial infarction. Hif2α in neutrophils supports neutrophil survival via cIAP-1 signaling and delays macrophage engulfment.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00392.2024

Authors: Enzo B. Piccolo, Zhi-Dong Ge, Mallory E. Filipp, David P. Sullivan, Edward B. Thorp, Ronen Sumagin

Institution: Northwestern University

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1271527374, G2731882162, Aging Exacerbates Neutrophil Persistence and Negatively Impacts Stroke Outcomes, Neutrophils instruct macrophage responses to promote mucosal healing, G7078043701, G9000029491, The Robert H. Lurie Comprehensive Cancer Center, Vascular endothelial cells and macrophages coordinate neutrophil trafficking in inflammation

OpenAlex ID: W4402920479

FWCI: 1.6

Cites: 45

Cited by: 6

Related to: 10