Year: 2024
Type: article
Abstract: Natural products have been a reliable source of drug compounds in medical research. Technological advances have led to the discovery and characterization of many compounds that were previously difficult to isolate. However, when searching for anticancer drugs, finding natural compounds that can bind to specific targets is a daunting task. Polycyclic tetramate macrolactams (PoTeMs), specifically, have been a source of antibiotics for a long time, though they possess certain cytotoxic properties that make them attractive candidates for anticancer drug discovery. This review covers the structural diversity and widespread availability of PoTeM compounds and the past research that demonstrates their effects on human cancer cell lines. Additionally, this review documents the known receptors and molecular mechanisms of these compounds in mammalian cells.
Source: Organics
DOI: 10.3390/org5040019
Institutions: Ohio University, Pontificia Universidad Católica del Ecuador
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,137
Funder: Ohio University
OpenAlex ID: W4402923014