Work

Characterization and biocompatibility of a bilayer PEEK-based scaffold for guiding bone regeneration

Year: 2024

Type: article

Abstract: BACKGROUND: Polyetheretherketone (PEEK) is well known for its excellent physical-chemical properties and biosafety. The study aimed to open up a new method for clinical application of PEEK to reconstruct large-scale bone defects. METHODS: A bilayer scaffold for bone regeneration was prepared by combining a sulfonated PEEK barrier framework (SPEEK) with a hydrogel layer loaded with aspirin (ASA) and nano-hydroxyapatite (nHAP) by the wet-bonding of Polydopamine (PDA). RESULTS: The hydrogel was successfully adhered to the surface of SPEEK, resulting in significant changes including the introduction of bioactive groups, improved hydrophilicity, and altered surface morphology. Subsequent tests confirmed that the bilayer scaffold exhibited enhanced compression resistance and mechanical compatibility with bone compared to a single hydrogel scaffold. Additionally, the bilayer scaffold showed stable and reliable bonding properties, as well as excellent biosafety verified by cell proliferation and viability experiments using mouse embryo osteoblast precursor (MC3T3-E1) cells. CONCLUSION: The bilayer bone regeneration scaffold prepared in this study showed promising potential in clinical application for bone regeneration.

Source: BMC Oral Health

DOI: 10.1186/s12903-024-04909-z

Authors: Shaoping Li, Cancan Jia, Haitong Han, Yuqing Yang, Yundeng Xiaowen, Zhiyu Chen

Institution: Hebei Medical University

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090