Work

New Tricyclic Aryl Quinazoline Derivatives by Suzuki‐Miyaura Cross‐Coupling

Year: 2024

Type: article

Abstract: A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.

Source: ChemistryOpen

DOI: 10.1002/open.202400197

Authors: Burkhon Elmuradov, Rasul Okmanov, Bakhromjon Juraev, Gerald Dräger, Holger Butenschön

Institutions: Leibniz University Hannover, Academy of Sciences Republic of Uzbekistan, Yunusov Institute of the Chemistry of Plant Substances

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,540

Funders: Alexander von Humboldt-Stiftung, Deutscher Akademischer Austauschdienst