Year: 2024
Type: article
Abstract: To inhibit the growth and metastasis of triple‐negative breast cancer (TNBC), two Fe(III) thiosemicarbazone complexes ( Fe1 and Fe2 ) were designed and synthesized. The structures of the Fe(III) complexes were characterized by single crystal X‐ray diffraction. The antiproliferative activity of Fe1 and Fe2 against four cancer lines (MDA‐MB‐231, T98G, HepG2, 143B) and human renal proximal tubular epithelial cell line (HK‐2) was evaluated by MTT assay. Among all cells, Fe2 showed significant cytotoxicity to TNBC cells (MDA‐MB‐231), with an IC 50 value of 12.38 μM. Furthermore, Fe2 showed less toxicity to HK‐2 cells. The two Fe(III) complexes can produce excess of reactive oxygen species, decrease of mitochondrial membrane potential, and induce DNA damage, then lead to apoptosis of MDA‐MB‐231 cells. In addition, Fe1 and Fe2 can also inhibit migration and invasion of MDA‐MB‐231 cells. This study provides guidance for the development of metal complexes that inhibit the growth and metastasis of TNBC.
Source: Drug Development Research
DOI: 10.1002/ddr.22264
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402926974