Work

Synthesis of New Tetracyclic Ring Systems: Bridged Derivatives of Hydroxy‐, Sulfanyl‐ and Amino‐Substituted Dibenzo[c,f][1,2]Thiazepine S,S‐Dioxides

Year: 2024

Type: article

Abstract: In continuation of our commitment to the synthesis of new ring systems based on the 6,11‐dihydrodibenzo[c,f][1,2]thiazepine 5,5‐dioxide core of the antidepressant drug tianeptine, we have incorporated two‐ and/or three‐carbon bridges between the nitrogen atom of the sulfonamide moiety and the N‐, O‐ or S‐substituent at position 11 of the tricycle. The synthesis of 5 new ring systems is described and demonstrated with several target compounds.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202400835

Authors: Gábor Berecz, Dávid Szabó, András Dancsó, Mária Tóthné Lauritz, Loránd Kiss, Gyula Simig, Balázs Volk

Institutions: Egis Pharmaceuticals (Hungary), Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences

Language: English

Topic: Phenothiazines and Benzothiazines Synthesis and Activities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

OpenAlex ID: W4402930525

FWCI: 0.462

Cites: 22

Cited by: 4

Related to: 10