Protocol for hydroxylating aryl chlorides catalyzed by photouranium with water under ambient conditions
Year: 2024
Type: article
Abstract: Here, we present a protocol for the hydroxylation of aryl chlorides catalyzed by photouranium with water under ambient conditions. We describe steps for gram-scale hydroxylation of 2′-chloroacetophenone using our self-designed continuous-flow photoreactor. We then detail procedures for obtaining 2′-hydroxyacetophenone using our self-designed rapid separation and purification instrument. This protocol is not suitable for polycyclic and heterocyclic aryl chlorides. For complete details on the use and execution of this protocol, please refer to Sun et al. 1 • Monitor the reaction via TLC Monitor-DQ • Small-scale parallel synthesis via PhotoSyn-10 • Steps for purifying of the crude product via AutoSepa-MJL Late-stage • Steps for gram-scale preparation via continuous flow photoreactor Photoflux-YX Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics. Here, we present a protocol for the hydroxylation of aryl chlorides catalyzed by photouranium with water under ambient conditions. We describe steps for gram-scale hydroxylation of 2′-chloroacetophenone using our self-designed continuous-flow photoreactor. We then detail procedures for obtaining 2′-hydroxyacetophenone using our self-designed rapid separation and purification instrument. This protocol is not suitable for polycyclic and heterocyclic aryl chlorides.
Source: STAR Protocols
Authors: Chengliang Li, Leiyang Bai, Xuefeng Jiang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4402932165