Bio‐MOFs Based on Natural Phenolic, Hematoxylin Leverages Biomedical Applications: Enzyme Inhibition, Antioxidant, and Antibacterial Properties
Year: 2024
Type: article
Abstract: Here, using natural hematoxylin (HT) as linker, metal‐organic frameworks (MOFs) from Cu(II), Fe(II), and Fe(III) ions was prepared. The SEM images and DLS analyses revealed HT‐based MOFs are 2/g for HT−Fe(III) MOFs. Interestingly, HT‐based MOFs exhibit fluorescent properties at λem=330 nm with fluorescence intensities of 11485, 2120, and 6790 (a.u) for HT−Cu(II), Fe(II), and Fe(III) MOFs, respectively. Moreover, HT‐based MOFs inhibited α‐glucosidase enyzme in a concentration‐dependent manner e. g., 33.1 %, 69.8 %, and 59.7 % of Cenzyme=500 mg/mL was inhibited by HT−Cu(II)‐MOF, HT−Fe(II)‐MOF, and HT−Fe(III)‐MOFs, respectively. The minimum bactericidal concentration (MBC) values of HT−Cu(II) MOFs for Escherichia coli (gram −), Staphylococcus aureus (gram +), and Candida albicans are determined as 5, 5, and 10 mg/mL, respectively. Also, the antioxidant activities of 250 ppm HT‐based MOF based on total phenol content (TPC) tests revealed 279, 208, 124, and 152 mg.gallic acid equivalent/mL (mg GA equivalency/mL) for HT, HT−Cu(II) MOF, HT−Fe(II) MOF, and HT−Fe(III), respectively affirming that antioxidant properties were retained. Moreover, HT−Fe(II) and HT−Fe(III) MOFs (62.5 μg/mL) against human null‐1 lung cell line revealed cell viabilities of 98.7±12.2 % and 88.9±11.7 %, respectively as concentration‐dependent biocompatibility of MOFs.
Source: Chemistry & Biodiversity
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4402932873