Work

Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Year: 2024

Type: article

Abstract: Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson's disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

Source: npj Parkinson s Disease

DOI: 10.1038/s41531-024-00797-w

Authors: Lvpiao Zheng, Ziling Luo, Biswaranjan Mohanty, Sana Amoozegar, Luke A. Johnson, Jerrold L. Vitek, Jing Wang

Institution: University of Minnesota

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,590

Funders: U.S. Department of Health and Human Services, University of Minnesota, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: G1316939693, G1652678203, G1810632041, G2556403304, G3083496518, G3377791784, G4172390600, Circuit-based deep brain stimulation for Parkinson's disease, Deep Brain Stimulation in the Parkinsonian Monkey, Optimizing coordinated reset deep brain stimulation for Parkinson's disease, G7458512065, Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey, G8789522263, G8924913809, G9000102408, G9000111797, G9000227161, Neurophysiological Mechanisms Underlying Parkinsonian Motor Signs

OpenAlex ID: W4402937928

FWCI: 0.686

Cites: 35

Cited by: 3

Related to: 10