Work

Sarcomatoid Morphology in Pediatric Langerhans Cell Neoplasm Does Not Always Predict Aggressive Clinical Course

Year: 2024

Type: article

Abstract: Langerhans cell sarcoma (LCS), a rare malignant neoplasm in the general category of myeloid neoplasms characterized by overtly malignant Langerhans cells (LC) with conspicuous mitotic activity including atypical forms. Although most cases occur in adults, rare examples of LCS have been reported in children with variable clinical outcome. We present 2 childhood cases of Langerhans cell neoplasm with high grade sarcomatous features and OSBPL9::BRAF fusion and BRAF V600E mutation.

Source: Pediatric and Developmental Pathology

DOI: 10.1177/10935266241281517

Authors: Sam Sirotnikov, Louis P. Dehner, José E. Velázquez Vega, Jinjun Cheng

Institutions: Emory University, Children's Healthcare of Atlanta, Washington University in St. Louis, Children's National, George Washington University

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4402939965

FWCI: 0.235

Cites: 29

Cited by: 1

Related to: 10