Year: 2024
Type: conference-paper
Abstract: Self-assembling cyclic peptides are important building blocks to construct synthetic nanotubes.They can be primarily classified into cyclic α-alt(D,L)-peptides, cyclic β-peptides, cyclic α,γ-peptides, and cyclic peptides incorporating δor ε-amino acids based on their composition.1 Our research focuses on design of novel cyclic peptides derived from β(O)-δ 5 -amino acid residues, consisting of a hybrid structure of crown ether and peptide macrocycles.These peptides exhibit unique self-assembly, forming hollow sub-nanotubular structures with unidirectional hydrogen bonds.These cyclic dipeptides, adopting non-centrosymmetric space groups, display significant anisotropy, suggesting potential macroscopic dipole extensions. 2 Furthermore, their inherent macrodipole orientation inspires investigation into their piezoelectric properties, opening new avenues for diverse applications.Additionally, we have synthesized size-variant macrocycles featuring β(O)-δ 5 amino acid residues which also fold into self-assembled nanotubes in solution and gas phase.This apparent supramolecular size-variant nanotube acts as an anion-selective transporter.The ion channel activity and selective transport of these structures are examples of the great potential that cyclic peptide nanotubes show for the construction of functional artificial transmembrane transporters.
Source: European Peptide Symposium (EPS)
Authors: Souvik Panda Mahapatra, Hosahudya N. Gopi
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4402942191