A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials
Year: 2024
Type: article
Abstract: Inspired by the scar-free wound healing in infants, an anti-scar strategy is proposed by accelerating wound healing using silicate bioactive materials. Bioglass/alginate composite hydrogels are applied, which significantly inhibit scar formation in rabbit ear scar models. The underlining mechanisms include stimulation of Integrin Subunit Alpha 2 expression in dermal fibroblasts to accelerate wound healing, and induction of apoptosis of hypertrophic scar fibroblasts by directly stimulating the N-Acylsphingosine Amidohydrolase 2 expression in hypertrophic scar fibroblasts, and indirectly upregulating the secretion of Cathepsin K in dermal fibroblasts. Considering specific functions of the bioactive silicate materials, two scar treatment regimes are tested. For severe scars, a regenerative intervention is applied by surgical removal of the scar followed by the treatment with bioactive hydrogels to reduce the formation of scars by activating dermal fibroblasts. For mild scars, the bioactive dressing is applied on the formed scar and reduces scar by inducing scar fibroblasts apoptosis.
Source: Advanced Science
Authors: Zhaowenbin Zhang, Chen Fan, Qing Xu, Feng Guo, Wenbo Li, Zhen Zeng, Yuze Xu, Jing Yu, Hongping Ge, Chen Yang, Jiang Chang
Institutions: Chinese Academy of Sciences, First Affiliated Hospital of Wenzhou Medical University, Shanghai Institute of Ceramics, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Wenzhou Institute, University of Chinese Academy of Sciences, Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,120
Funders: Wenzhou Medical University, National Natural Science Foundation of China, Chinese Academy of Sciences, China Postdoctoral Science Foundation, Shanghai Jiao Tong University, University of Chinese Academy of Sciences, School of Medicine, Shanghai Jiao Tong University, Wenzhou Institute of Biomaterials and Engineering, Science and Technology Plan Project of Wenzhou, China
OpenAlex ID: W4402943294