Work

Histoplasma Capsulatum Infection With Both Granulomatous Features and Fibrosing Mediastinitis Presenting as Shortness of Breath: A Case Report

Year: 2024

Type: article

Abstract: It is known that Histoplasma capsulatum can cause chronic granulomatous disease or fibrosing mediastinitis, but both presentations occurring in the same patient is exceedingly rare and difficult to diagnose. The patient is a 24-year-old female with a past medical history of asthma, who presented for worsening shortness of breath. Thoracic imaging revealed a large paratracheal mass with a significant mass effect. Endobronchial ultrasound (EBUS) was attempted unsuccessfully, and the patient underwent video-assisted thoracoscopic surgery, which established the diagnosis of fibrosing mediastinitis. Extensive infectious disease workup confirmed Histoplasma infection. She was treated with a course of Itraconazole, pulmonary artery stenting, and rituximab.

Source: Cureus

DOI: 10.7759/cureus.70398

Authors: Ryan M Kozloski, Alec K Donohue, Preston J Sparks, Janelle L Robertson, David C Hostler

Institutions: Womack Army Medical Center, Fayetteville VA Medical Center

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402946353