Work

Integrated analysis of circRNA regulation with ADARB2 enrichment in inhibitory neurons

Year: 2024

Type: article

Abstract: This study investigates the regulation of circular RNAs (circRNAs) with Adenosine Deaminase RNA Specific B2 (ADARB2) enrichment specifically in inhibitory neurons. Using an integrated analysis combining high-throughput sequencing and bioinformatics approaches, we identified a group of circRNAs that are potentially enhanced by ADARB2. Our findings highlight the pivotal role of ADARB2 in circRNA synthesis within inhibitory neurons, likely through its specific binding to precursor RNAs, which facilitates circRNA biogenesis.

Source: Computers in Biology and Medicine

DOI: 10.1016/j.compbiomed.2024.109212

Authors: Suwan Yu, Hongseok Ha, Kwangsoo Kim

Institutions: Seoul National University, Seoul National University Hospital, Seoul National University Hospital Institute of Convergence Medicine with Innovative Technology

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,640