Research Progress on Mechanism of Chinese Medicine Intervention on Cuprotosis Induced Apoptosis of Tumor Cells
Year: 2024
Type: article
Abstract: In the current field of cancer treatment, the search for new therapeutic targets and methods remains a focal area of research. Traditional Chinese medicine contains a variety of pharmacologically active components that interact with multiple targets and signaling pathways in the human body, demonstrating potential anti-tumor effects. Copper plays a crucial role in various physiological processes; its homeostasis is tightly regulated to limit the production of oxidative stress and toxicity, and it intervenes in the processes of tumor development, metastasis, and recurrence. Cuproptosis represents a novel form of copper-dependent cell death that differs from previously known regulatory cell death mechanisms, offering a fresh perspective on the link between copper homeostasis and mitochondrial metabolism. Targeting copper has emerged as a new anti-cancer strategy. Current research on the intervention of cuproptosis by TCM is limited; leveraging the advantages of TCM's multi-target, multi-pathway approach could further elucidate the mechanisms of cuproptosis, bringing more possibilities to cancer treatment modalities.
DOI: 10.54097/ah3vsh76
Authors: Xingsheng Wang, Qishun Qin, Shihong Xu
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402961609