The protective effects of L-Carnitine against oxidative toxicity in adult male New Zealand Rabbits
Year: 2024
Type: article
Abstract: To determine the effectiveness of L-carnitine in reducing oxidative stress in male New Zealand rabbits, twenty adult rabbits were used in this study and randomly divided into four groups: G I (Control): Standard diet and water, G II (OX): 0.5% H2O2 in drinking water with a standard diet, G III (LCA): 150 mg L-carnitine/kg feed with regular water, and G IV (PCO): 150 mg Lcarnitine/kg feed with 0.5% H2O2 in drinking water. There was no significant effect of adding L-carnitine on most blood parameters in normal or oxidative stress-exposed rabbits. However, LCA treatment significantly increased total protein and albumin levels and decreased glucose levels. OX group showed higher levels of GOT, GPT, and MDA, while these parameters improved in the LCA group, which also showed superior GSH levels. L-carnitine treatment significantly improved cortisol and testosterone levels, suggesting it protects the male reproductive system from free radical damage by improving blood parameters and reducing oxidative stress.
Authors: Ahmed Taies, Eman Al-Samarai
Institution: Ministry of Education
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Tikrit University
OpenAlex ID: W4402975056