Year: 2024
Type: conference-abstract
Abstract: The building block Fmoc-ehr=Pro-OH can be synthesized in a 9 step synthesis with the LEMIEUX-JOHNSON oxidation as the key step.With this dipeptide the synthesis of the peptide natural product fusahexin was possible and 10 mg were isolated as a white solid.Because of the similiarity to the dipeptide which BALDWIN & CLARIDGE proposed as a 𝛽-turn mimic the Fmoc-ehr=Pro-OH building block is a possible 𝛽-turn mimic.In further studies the building bock is going to be used in more different peptide sequences to see if it is introducing a 𝛽-turn.Bioactivity studies are in progress. References Conclusion and Outlook Modeling
Source: European Peptide Symposium (EPS)
Authors: Carmen Bäuerlein, Armin Geyer
Institution: Philipps University of Marburg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4402986713