Work

Migratory autolysosome disposal mitigates lysosome damage

Year: 2024

Type: article

Abstract: Lysosomes, essential for intracellular degradation and recycling, employ damage-control strategies such as lysophagy and membrane repair mechanisms to maintain functionality and cellular homeostasis. Our study unveils migratory autolysosome disposal (MAD), a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring autophagy machinery, SNARE proteins, and cell migration. This mechanism, crucial for mitigating lysosomal damage, underscores the role of cell migration in lysosome damage control and facilitates the release of small extracellular vesicles, highlighting the intricate relationship between cell migration, organelle quality control, and extracellular vesicle release.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202403195

Authors: Takami Sho, Ying Li, Haifeng Jiao, Li Yu

Institutions: Peking University, Center for Life Sciences, State Key Laboratory of Membrane Biology, Tsinghua University

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Tsinghua University, Beijing Municipal Science and Technology Commission, State Key Laboratory of Membrane Biology

Awards: G2580356833, G3909598438, G4735130173, G7288762016, G8515012641