Water Participated Dual C(sp 3 )−C(sp 3 ) Bond Cleavage of Cyclobutanones Catalyzed by Lewis Acid
Year: 2024
Type: article
Abstract: Lewis acid‐catalyzed ring‐opening reactions of cyclobutanones were mostly achieved through cleavage of a single C2−C3 bond to deliver cyclic products. Herein, an unprecedented Lewis acid catalyzed synergistic cleavage of both C2−C3 bonds in 3‐arylcyclobutanones was realized under participation of water, providing a series of aryl alkyl ketones in mild conditions. A broad scope of substrates decorated with various substituents were well accommodated. Mechanistic proposal including the function of water was unambiguously validated by experimental verification.
Source: ChemistrySelect
Authors: Dong‐Yue Zhang, Jie Tao, Zu‐Yong Liu, Tian‐Gui Li, Wen‐Hui Ma, Ting‐Ting Li, Yuanqi Wu, Yu Liu
Institution: Changchun University of Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G4964301735
OpenAlex ID: W4402988328