Work

Aspilactonol J: A New Cytotoxic Polyketide Isolated from the Marine-Derived Fungus Aspergillus sp. w2-13

Year: 2024

Type: article

Abstract: Marine-derived Aspergillus sp. strain w2-13, isolated from Dongshan Island in Fujian Province, produced five compounds through solid-state fermentation. This included a new polyketide, aspilactonol J (1), and four previously identified compounds (2–5). The structure of the new compound was determined using NMR, HR-MS, and ECD, supported by theoretical calculations. A plausible biosynthetic pathway for polyketides 1–3 was also proposed. Cytotoxicity tests on various cancer cell lines revealed that aspilactonol J (1) exhibited significant selectivity and efficacy, especially against HepG2 cells, suggesting its potential for pharmaceutical development. This study highlights the role of marine fungi as valuable sources of bioactive natural products with therapeutic potential.

Source: Records of Natural Products

DOI: 10.25135/rnp.477.2406.3552

Authors: Xiaomei Huang, Shan Lin, Guangyu Li, Zongze Shao, Weiyi Wang, Jinmei Xia

Institutions: Ministry of Natural Resources, Third Institute of Oceanography

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Natural Science Foundation of Fujian Province, Xiamen Southern Oceanographic Center, China Ocean Mineral Resources Research and Development Association, National Key Research and Development Program of China