First Detection and Characterization of Smacovirus in the Human Vagina in Two Sequential Samples over a Twelve-Day Interval
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Smacovirus is a CRESS-DNA virus identified almost exclusively in transient fecal samples from various vertebrate species. Objective: We evaluated human vaginal samples for the presence and maintenance of Smacovirus. Methods: Viral metagenomics analysis was performed on vaginal samples collected from 28 apparently healthy women in New York City, USA. Twenty-one of the women provided duplicate samples over a 12–21-day interval. Results: Phylogenetic analysis identified two samples from the same individual, collected over a twelve-day interval, that were positive for the complete Smacovirus genome. All detected sequence contigs belonged to a single variant of CRESS-DNA. Conclusions: The continuous presence of Smacovirus in the human vagina over a twelve-day period was identified.
Source: Viruses
DOI: 10.3390/v16101545
Authors: Antonio Charlys da Costa, Tania Regina Tozetto-Mendoza, Endrya do Socorro Foro Ramos, Pietro Bortoletto, Noely Evangelista Ferreira, Layla Honorato, Erick Matheus Garcia Barbosa, Heuder Gustavo Oliveira Paião, Amanda Fernandes de Souza, Iara M. Linhares, Steven D. Spandorfer, Elcio Leal, Maria Cassia Mendes-Correa, Steven S. Witkin
Language: English
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,955
OpenAlex ID: W4402992293