Work

Machine learning optimized DriverDetect software for high precision prediction of deleterious mutations in human cancers

Year: 2024

Type: article

Abstract: The detection of cancer-driving mutations is important for understanding cancer pathology and therapeutics development. Prediction tools have been created to streamline the computation process. However, most tools available have heterogeneous sensitivity or specificity. We built a machine learning-derived algorithm, DriverDetect that combines the outputs of seven pre-existing tools to improve the prediction of candidate driver cancer mutations. The algorithm was trained with cancer gene-specific mutation datasets of cancer patients to identify cancer drivers. DriverDetect performed better than the individual tools or their combinations in the validation test. It has the potential to incorporate future novel prediction algorithms and can be retrained with new datasets, offering an expanded application to pan-cancer analysis for cross-cancer study. (115 words).

Source: Scientific Reports

DOI: 10.1038/s41598-024-71422-2

Authors: Herrick Yu Kan Koh, Ulysses Tsz Fung Lam, Kenneth Hon-Kim Ban, Ee Sin Chen

Institutions: National University of Singapore, National University Health System

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590