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Synthesis, Characterization and Antifungal Studies of Novel Substituted Benzaldehyde Derivatives of 2-Amino-6-ferrocenyl-4-phenylpyrimidine

Year: 2024

Type: article

Abstract: A series of novel 2-amino-6-ferrocenyl-4-phenylpyrimidine (AFPP) derivatives (6a-j) have been synthesized by coupling AFPP with thioglycolic acid and various substituted benzaldehydes (a-j) using standard 1,3-dicyclohexylcarbodiimide (DCC) protocol. The synthesized compounds were characterized by FTIR, 13C NMR, 1H NMR and MS techniques. The synthesized compounds 6a-j were evaluated for antifungal activities against Candida albicans MTCC 183. Comparing compounds 6a-j to standard amphotericin B, it was found that the synthesized compounds showed excellent activity.

Source: Asian Journal of Chemistry

DOI: 10.14233/ajchem.2024.32303

Authors: Ajitkumar Vijay Ingle, Shrimant Vhannappa Rathod

Language: English

Topic: Ferrocene Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403000651

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