Work

Novel use of adjuvant proton beam therapy in patient with pelvic renal transplant diagnosed with stage IB3 cervical adenocarcinoma

Year: 2024

Type: article

Abstract: • Pelvic radiotherapy in patients with transplanted kidneys poses unique clinical challenges. • Proton therapy has been used in gynecologic cancers post-hysterectomy with reduced dose to pelvic organs at risk. • Patient with renal transplant and early-stage, intermediate-risk cervical cancer treated with surgery and proton therapy. • Treatment was well tolerated with a disease-free interval of 14 months and preserved renal function. • Case highlights the advantage of shared decision-making and novel use of proton therapy in treating gynecological cancer. Cervical adenocarcinoma is the second most common histology of cervical cancer and treatment can involve surgery, radiotherapy, systemic therapy, and any combination of the three. Photon external beam radiation therapy and brachytherapy have been the mainstay of radiation treatment options for cervical cancer. Here, we report a case of a 41-year-old patient who had a prior renal transplant and was diagnosed with early-stage, intermediate-risk adenocarcinoma treated with modified radical hysterectomy plus adjuvant proton-beam therapy and vaginal brachytherapy. Treatment was well tolerated with a disease-free interval of 14-months and preserved renal function.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2024.101520

Authors: Pedro Versuti Del Cioppo Vasques, Jamie N. Bakkum-Gamez, Patrick G. Dean, Jeremy F. Molligan, Allison E. Garda

Institution: Mayo Clinic

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750