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Exploratory study on physicochemical properties of nitazoxanide nanocrystalline suspension obtained by evaporative solvent-antisolvent technique

Year: 2024

Type: article

Abstract: Nitazoxanide (NTZ) is a broad-spectrum antiparasitic drug with low bioavailability due to its poor aqueous solubility, classified as a Biopharmaceutical Classification System (BCS) class II drug. This study aimed to improve the understanding of NTZ nanocrystalline suspensions produced via the solvent-antisolvent technique. NTZ was extracted from commercially available coated tablets and characterized using DSC, TG, UV-Vis, and FTIR, revealing the presence of impurities likely from excipients. Nanocrystalline suspensions were prepared using three different stabilizers (Lecithin, Poloxamer 188, and Tween® 80) and evaluated for particle size distribution (PSD) and polydispersity index (PDI) over a one-week stability study. Poloxamer 188 was the most effective in reducing particle size (934.7 nm), though Lecithin achieved a more favorable PDI (0.289), indicating better particle uniformity. These findings suggest the solvent-antisolvent technique is a promising approach for producing NTZ nanocrystalline suspensions, but further reduction in particle size and exploration of alternative stabilizers are needed to optimize stability and performance.

Source: International Journal of Science and Research Archive

DOI: 10.30574/ijsra.2024.13.1.1807

Authors: Rui Filipe da Conceição Teixeira, Lucas Antunes Araújo, Gabriel Lima Barros de Araújo

Institution: Universidade de São Paulo

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4403002713