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Probiotic Lactiplantibacillus plantarum subsp. plantarum Dad-13 Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Through Short-Chain Fatty Acid Production and Inflammatory Cytokine Regulation

Year: 2024

Type: article

Abstract: The development of inflammatory bowel disease (IBD) is closely linked to inflammatory damage and dysbiosis.Recently, probiotics are being increasingly used to improve intestinal health.Probiotic-based therapies can prevent IBD by restoring the balance of gastrointestinal microbiota, reducing gut inflammation, and increasing the concentration of short-chain fatty acids (SCFAs).The present study aimed to investigate the protective effects of Lactiplantibacillus plantarum subsp.plantarum Dad-13, a novel probiotic strain derived from dadih (Indonesian curd from buffalo milk), on 2,4,6trinitrobenzene sulfonic acid (TNBS)-induced colitis in BALB/c mice.The results showed that probiotic Dad-13 supplementation at a dose of 10 7 or 10 9 CFU/mL improved the clinical symptoms of IBD and enhanced the production of SCFAs, particularly propionate and butyrate.Moreover, probiotic Dad-13 supplementation significantly decreased the levels of proinflammatory cytokines [tumor necrosis factor-, interleukin (IL)-6, and IL-1] and significantly increased the levels of antiinflammatory cytokines (IL-10).These findings show that L. plantarum Dad-13 can effectively prevent TNBS-induced colitis by modulating SCFA production and inflammatory cytokines.

Source: Preventive Nutrition and Food Science

DOI: 10.3746/pnf.2024.29.3.270

Authors: Rimba Bunga Pertiwi, Yosinta Christie Setiabudi, Yunika Mayangsari, Dian Anggraini Suroto, Endang Sutriswati Rahayu

Institution: Universitas Gadjah Mada

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Lembaga Pengelola Dana Pendidikan