Prokinetic agents in adult intensive care unit patients ( PATIENCE )—An international inception cohort study protocol
Year: 2024
Type: article
Study design: Study Protocol
Abstract: BACKGROUND: Feeding intolerance is common in critically ill patients and can lead to malnutrition. Prokinetic agents may be used to enhance the uptake of nutrition. However, the evidence on the effectiveness and safety of prokinetic agents is sparse, and there is a lack of data on their use in intensive care units (ICU). METHODS: We will conduct an international 14-day inception cohort study of 1000 acutely admitted adult ICU patients. Data will be collected from ICU admission and daily during ICU stay for up to 90 days. The primary outcome will be the proportion of ICU patients who receive prokinetic agents. Secondary outcomes include mortality, days alive without life support, days alive out of ICU, days alive out of hospital (all within 90 days) and the number of patients with one or more serious adverse events. RESULTS: We will present data on the use of prokinetic agents descriptively and use Cox regressions with death and ICU discharge as competing events to evaluate the association between patient characteristics and the use of prokinetic agents. We will use extended Cox models with time-varying covariates and linear regression models to assess the associations between the use of prokinetic agents and the secondary outcomes. CONCLUSION: The outlined international cohort study will provide valuable epidemiological data on the use of prokinetic agents in adult, acutely admitted ICU patients.
DOI: 10.1111/aas.14534
Authors: Vera Crone, Morten Hylander Møller, Anders Perner, Waleed Alhazzani, Anders Granholm, Laura Rindom Krogsgaard, Abdulrahman Al‐Fares, Johanna Hästbacka, Marlies Ostermann, Carmen A. Pfortmueller, Richard Ferrer, Annika Reintam Blaser, Martin I. Sigurdsson, Olof Wall, Eric Keus, Wojciech Szczeklik, Mette Krag
Institutions: Holbæk Sygehus, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, King Saud University, Research and Innovation Institute, Hvidovre Hospital, Amiri Hospital, Ministry of Health, Pirkanmaa Hospital District, Tampere University Hospital, Guy's Hospital, St Thomas' Hospital, King's College London, University of Bern, University Hospital of Bern, Vall d'Hebron Hospital Universitari, Luzerner Kantonsspital, University of Tartu, University of Iceland, National University Hospital of Iceland, Danderyds sjukhus, University Medical Center Groningen, Jagiellonian University
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,220
Funder: Novo Nordisk Fonden
Award: G8743750660
OpenAlex ID: W4403005350