Work

Diagnostic Potential of Combined Photoplethysmography and Ankle‐Brachial Index in Peripheral Arterial Disease: A Duplex Ultrasonography‐Based Comparative Study

Year: 2024

Type: article

Abstract: Background Although ankle‐brachial index (ABI) and photoplethysmography (PPG) have also shown adequate sensitivity in detecting peripheral arterial disease, their diagnostic performance is less reliable in asymptomatic cases or those with high atherosclerotic cardiovascular risks. Methods and Results We evaluated 130 participants using ABI, PPG, and duplex ultrasonography, diagnosing 65 with peripheral arterial disease. From the PPG, we derived 2 parameters: PPG amplitude ratio of the lower‐to‐upper extremities (PPG ratio ) and the PPG amplitude of the lower extremity (PPG amp ). Sensitivity, specificity, accuracy, and the area under receiver operating characteristic (ROC) curve were calculated for PPG parameters and ABI, and their combination of both methods. Univariate and multivariate logistic regression assessed the prognostic potential of these parameters. ROC analysis revealed optimal cutoff values in diagnosing peripheral arterial disease were 0.417 for PPG ratio and “58” for PPG amp . Both PPG ratio and PPG amp demonstrated significantly higher sensitivities, 78.4% and 75.7%, respectively, compared with 55.9% for ABI <0.9 ( P <0.05). The areas under the ROC curves of combination models, including model 1 (ABI <0.9 and PPG ratio ), model 2 (ABI <0.9 and PPG amp ), and model 3 (ABI <0.9, PPG ratio , and PPG amp ), exhibited improved performance with areas under the ROC curves of 0.922, 0.922, and 0.931 (all P <0.01) compared with ABI alone (area under the ROC curve, 0.822). Additionally, the PPG parameters, both alone and combined with ABI, were associated with major adverse cardiac events and all‐cause mortality after adjusting for other relevant factors. Conclusions On the basis of duplex ultrasonography, combining ABI and PPG markedly improves peripheral arterial disease diagnosis in high‐risk individuals compared with either method alone and provides crucial insights into major adverse cardiac events and all‐cause mortality risks.

Source: Journal of the American Heart Association

DOI: 10.1161/jaha.124.034625

Authors: Han‐Luen Huang, Chia‐Hsiu Chang, Men‐Tzung Lo, Chen Lin

Institutions: Minghsin University of Science and Technology, National Central University, Cathay General Hospital

Language: English

Topic: Peripheral Artery Disease Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,700